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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Mini-Review Article

AD脑内D-丝氨酸水平动态变化的复杂过程

卷 19, 期 7, 2022

发表于: 31 May, 2022

页: [485 - 493] 页: 9

弟呕挨: 10.2174/1567205019666220328123048

价格: $65

摘要

背景：阿尔茨海默病（AD）是一种以细胞外β-淀粉样蛋白（aβ）斑块和认知障碍为特征的神经退行性疾病。D-丝氨酸由大脑中的丝氨酸外消旋酶（SR）产生，在N-甲基-D-天冬氨酸受体（NMDAR）的甘氨酸结合位点起内源性共激动剂的作用，与AD的病理生理过程有关。 目的：关于D-丝氨酸在AD进展过程中的作用和动态调节的理解证据仍有争议。本文献综述旨在为研究AD脑中D-丝氨酸的功能和代谢提供新的研究方向。 方法：我们使用D-丝氨酸/SR和AD作为关键词搜索PubMed。包括与NMDAR功能障碍、神经元兴奋毒性、D-丝氨酸动态变化和炎症反应相关的研究。 结果：这篇综述主要讨论了：（i）Aβ低聚物在NMDAR失调中的作用，以及AD中随后的突触功能障碍和神经元损伤，（ii）D-丝氨酸在NMDAR诱导的兴奋性毒性中的作用以及（iii）D-丝氨酸和SR参与AD相关的炎症病理进展。 结论：我们还提出了AD进展过程中D-丝氨酸的代谢和动态变化，并假设：（i）D-丝氨酸水平或SR表达的可能调节是缓解AD病理生理进展过程中神经毒性的有效方法，以及（ii）AD脑中D-丝氨酸水平的动态变化可能由复杂过程引起。

关键词: 阿尔茨海默病，D-丝氨酸，丝氨酸外消旋酶，NMDAR，认知，突触传递，神经变性。

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