Title:FER1L4: A Long Non-coding RNA with Multiple Roles in the Occurrence and
Development of Tumors
Volume: 28
Issue: 16
Author(s): Jie Mou, Bei Wang, Yuling Liu, Fengnan Zhao, Yinxin Wu, Wen Xu, Deyuan Zeng, Qi Zhang and Chengfu Yuan*
Affiliation:
- Medical College, China Three Gorges University, Yichang 443002, China
- Third-grade Pharmacological Laboratory on Traditional
Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, China
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China
Keywords:
Long non-coding RNA, FER1L4, biological marker, target, diagnosis, malignancy, prognosis, mechanism.
Abstract:
Background: FER-1 family member 4 (FER1L4), a 6.7 kb lncRNA located at 20q11.22, plays an
important biological function in a variety of tumor diseases. The purpose of this review is to clarify the pathophysiological
mechanism and potential biological function of FER1L4 in different tumors.
Methods: By searching the relevant literature in PubMed, the specific pathophysiological mechanism of
FER1L4 in different tumors was summarized.
Results: LncRNA FER1L4 is one of the key factors in tumorigenesis and is abnormally down-regulated in
many tumors, including osteosarcoma, lung cancer, laryngeal squamous cell carcinoma, laryngeal cancer, colorectal
cancer, ovarian cancer, prostate cancer, esophageal cancer, gastric cancer, endometrial cancer, osteoarthritis,
rheumatoid arthritis, and so on. However, FER1L4 is downregulated in breast cancer, glioma, oral
squamous cell carcinoma, renal clear cell carcinoma, and periodontitis, and plays a protective role in orthodontic
teeth. In addition, as a tumor suppressor gene or oncogene, FER1L4 affects tumor proliferation, invasion,
migration, and apoptosis.
Conclusion: LncRNA FER1L4 has a good application prospect in the treatment and diagnosis of various
tumors.
