Title:The Marriage between Nanotechnology and Stem Cells Secretome for
COPD
Volume: 23
Issue: 7
Author(s): Avinash Kharat, Avinash Sanap, Madhura Shekatkar, Supriya Kheur and Ramesh Bhonde*
Affiliation:
- Regenerative Medicine Laboratory, Dr. D.Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra 411018, India
Keywords:
Nanoparticles, mesenchymal stem cells, secretome, regenerative medicine, chronic obstructive pulmonary disease, drug delivery.
Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a disorder characterized by narrow
alveoli as a result of emphysema. As such, there is no treatment to cure this disorder completely, and
existing drugs only delay the progression of the disease. In recent years, the stem cell secretome as a
drug is remarkably used as a regenerative therapy. In particular, cell-free therapy approaches offer
great opportunities for the treatment of COPD. However, a few issues, such as the delivery of stem
cell secretome as a drug to the alveolar region, have obstructed their application in clinical scales. To
address these challenges, a combination of stem-cells secretome as a drug with nanotechnology could
be a smart solution. We suggest that the combinational approach of delivering nanoparticles loaded
with stem cell secretome could be a translational medicine approach for the successful outcome of
COPD.
