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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

Roles of Gut Microbiota in Colorectal Carcinogenesis Providing a Perspective for Early Diagnosis and Treatment

Author(s): Roghayeh Nouri, Alka Hasani, Mohammad Asgharzadeh, Fatemeh Yeganeh Sefidan, Fatemeh Hemmati and Mohammad Ahangarzadeh Rezaee*

Volume 23, Issue 13, 2022

Published on: 21 April, 2022

Page: [1569 - 1580] Pages: 12

DOI: 10.2174/1389201023666220307112413

Price: $65

Abstract

Colorectal cancer (CRC) is the third most prevalent malignant neoplasm in the world. CRC is influenced by both environmental and genetic factors. Through toxin-mediated DNA damage and the promotion of persistent dysregulated inflammation, the gut microbiota plays a crucial role in the development of CRC. In this review, we discussed the correlation between the bacterial microbiota and CRC carcinogenesis as well as the mechanism by which Streptococcus bovis/gallolyticus, Fusobacterium nucleatum, Bacteroides fragilis, and Escherichia coli can cause CRC.

Keywords: Gut microbiota, bacteria, colorectal cancer, carcinogenesis, inflammation, genotoxicity.

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