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ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

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Pediatric Takayasu Arteritis: A Review of the Literature

Author(s): Fatih Haslak, Mehmet Yildiz, Sezgin Sahin, Amra Adrovic, Kenan Barut and Ozgur Kasapcopur*

Volume 18, Issue 4, 2022

Published on: 12 April, 2022

Page: [243 - 250] Pages: 8

DOI: 10.2174/1573396318666220304205518

Price: $65

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Abstract

Takayasu arteritis (TA) is the third most common vasculitis of childhood and is extremely rare. It is mainly characterized by chronic, autoimmune, and granulomatous inflammation of the aorta and its major branches. Women under 40 years of age are mostly affected. It occurs for the first time in childhood in about 30% of affected individuals. Initially, it presents nonspecific constitutional findings. Since there is no specific laboratory finding, diagnosis is challenging. The gold standard imaging method for diagnosis is conventional angiography. Delay in diagnosis can cause devastating consequences. Therefore, in cases presenting with nonspecific findings, with hypertension and high acute phase reactants, the diagnosis should be suspected and confirmed with appropriate imaging method, and treatment should be started immediately. Immunosuppressive agents are the mainstay of the treatment. Biological agents are successful in refractory cases, and endovascular revascularization methods are used in the treatment of complications.

Keywords: Takayasu arteritis, systemic vasculitis, rheumatoid vasculitis, pediatrics, rheumatology, hypertension.

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[1]
Mathew AJ, Goel R, Kumar S, Danda D. Childhood-onset Takayasu arteritis: An update. Int J Rheum Dis 2016; 19(2): 116-26.
[http://dx.doi.org/10.1111/1756-185X.12718] [PMID: 26585174]
[2]
Mason JC. Takayasu arteritis-advances in diagnosis and management. Nat Rev Rheumatol 2010; 6(7): 406-15.
[http://dx.doi.org/10.1038/nrrheum.2010.82] [PMID: 20596053]
[3]
Aeschlimann FA, Barra L, Alsolaimani R, et al. Presentation and disease course of childhood-onset versus adult-onset takayasu arteritis. Arthritis Rheumatol 2019; 71(2): 315-23.
[http://dx.doi.org/10.1002/art.40690] [PMID: 30101446]
[4]
Goel R, Sathish Kumar T, Danda D. Childhood-onset Takayasu arteritis (c-TA): Current and future drug therapy. Paediatr Drugs 2019; 21(2): 81-93.
[http://dx.doi.org/10.1007/s40272-019-00327-9] [PMID: 31087279]
[5]
Brunner J, Feldman BM, Tyrrell PN, et al. Takayasu arteritis in children and adolescents. Rheumatology (Oxford) 2010; 49(10): 1806-14.
[http://dx.doi.org/10.1093/rheumatology/keq167] [PMID: 20562196]
[6]
Cattalini M, Soliani M, Caparello MC, Cimaz R. Sex differences in pediatric rheumatology. Clin Rev Allergy Immunol 2019; 56(3): 293-307.
[http://dx.doi.org/10.1007/s12016-017-8642-3] [PMID: 28849549]
[7]
Mossberg M, Segelmark M, Kahn R, Englund M, Mohammad AJ. Epidemiology of primary systemic vasculitis in children: A population-based study from southern Sweden. Scand J Rheumatol 2018; 47(4): 295-302.
[http://dx.doi.org/10.1080/03009742.2017.1412497] [PMID: 29409373]
[8]
Goel R, Kumar TS, Danda D, et al. Childhood-onset Takayasu arteritis -- experience from a tertiary care center in South India. J Rheumatol 2014; 41(6): 1183-9.
[http://dx.doi.org/10.3899/jrheum.131117] [PMID: 24786922]
[9]
Chugh KS, Sakhuja V. Takayasu’s arteritis as a cause of renovascular hypertension in Asian countries. Am J Nephrol 1992; 12(1-2): 1-8.
[http://dx.doi.org/10.1159/000168409] [PMID: 1357971]
[10]
Dabague J, Reyes PA. Takayasu arteritis in Mexico: A 38-year clinical perspective through literature review. Int J Cardiol 1996; 54(Suppl.): S103-9.
[http://dx.doi.org/10.1016/S0167-5273(96)88779-1] [PMID: 9119510]
[11]
Rosenthal T, Morag B, Rubinstein Z, Itzchak Y. Takayasu arteritis in Israel--update. Int J Cardiol 1996; 54(Suppl.): S137-40.
[http://dx.doi.org/10.1016/S0167-5273(96)02812-4] [PMID: 9119515]
[12]
Di Santo M, Stelmaszewski EV, Villa A. Takayasu arteritis in paediatrics. Cardiol Young 2018; 28(3): 354-61.
[http://dx.doi.org/10.1017/S1047951117001998] [PMID: 29233197]
[13]
Kerr GS, Hallahan CW, Giordano J, et al. Takayasu arteritis. Ann Intern Med 1994; 120(11): 919-29.
[http://dx.doi.org/10.7326/0003-4819-120-11-199406010-00004] [PMID: 7909656]
[14]
Lupi-Herrera E, Sánchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE. Takayasu’s arteritis. Clinical study of 107 cases. Am Heart J 1977; 93(1): 94-103.
[http://dx.doi.org/10.1016/S0002-8703(77)80178-6] [PMID: 12655]
[15]
Karabacak M, Kaymaz-Tahra S, Şahin S, et al. Childhood-onset versus adult-onset Takayasu arteritis: A study of 141 patients from Turkey. Semin Arthritis Rheum 2021; 51(1): 192-7.
[http://dx.doi.org/10.1016/j.semarthrit.2020.10.013] [PMID: 33383295]
[16]
Morales E, Pineda C, Martínez-Lavín M. Takayasu’s arteritis in children. J Rheumatol 1991; 18(7): 1081-4.
[PMID: 1681102]
[17]
Watson L, Brogan P, Peart I, Landes C, Barnes N, Cleary G. Diagnosis and assessment of disease activity in Takayasu arteritis: A childhood case illustrating the challenge. Case Rep Rheumatol 2014; 2014: 603171.
[http://dx.doi.org/10.1155/2014/603171] [PMID: 24511407]
[18]
Eleftheriou D, Batu ED, Ozen S, Brogan PA. Vasculitis in children. Nephrol Dial Transplant 2015; 30(Suppl. 1): i94-i103.
[PMID: 25550447]
[19]
Peter J, David S, Danda D, Peter JV, Horo S, Joseph G. Ocular manifestations of Takayasu arteritis: A cross-sectional study. Retina 2011; 31(6): 1170-8.
[http://dx.doi.org/10.1097/IAE.0b013e3181fe540b] [PMID: 21317836]
[20]
Fieldston E, Albert D, Finkel T. Hypertension and elevated ESR as diagnostic features of Takayasu arteritis in children. J Clin Rheumatol 2003; 9(3): 156-63.
[http://dx.doi.org/10.1097/01.RHU.0000073436.33243.2c] [PMID: 17041451]
[21]
Yajima M, Moriwaki R, Numano F, Park YB, Cho YD. Comparative studies between Japanese and Korean patients: Comparison of the findings of angiography, HLA-Bw52, and clinical manifestations. Heart Vessels Suppl 1992; 7: 102-5.
[http://dx.doi.org/10.1007/BF01744553] [PMID: 1360952]
[22]
Misra DP, Aggarwal A, Lawrence A, Agarwal V, Misra R. Pediatric-onset Takayasu’s arteritis: Clinical features and short-term outcome. Rheumatol Int 2015; 35(10): 1701-6.
[http://dx.doi.org/10.1007/s00296-015-3272-7] [PMID: 25903354]
[23]
Eleftheriou D, Varnier G, Dolezalova P, McMahon AM, Al-Obaidi M, Brogan PA. Takayasu arteritis in childhood: Retrospective experience from a tertiary referral centre in the United Kingdom. Arthritis Res Ther 2015; 17(1): 36.
[http://dx.doi.org/10.1186/s13075-015-0545-1] [PMID: 25879697]
[24]
Zhu WH, Shen LG, Neubauer H. Clinical characteristics, interdisciplinary treatment and follow-up of 14 children with Takayasu arteritis. World J Pediatr 2010; 6(4): 342-7.
[http://dx.doi.org/10.1007/s12519-010-0234-8] [PMID: 21080146]
[25]
Szugye HS, Zeft AS, Spalding SJ. Takayasu arteritis in the pediatric population: A contemporary United States-based single center cohort. Pediatr Rheumatol Online J 2014; 12: 21.
[http://dx.doi.org/10.1186/1546-0096-12-21] [PMID: 24955077]
[26]
Aeschlimann FA, Eng SWM, Sheikh S, et al. Childhood Takayasu arteritis: Disease course and response to therapy. Arthritis Res Ther 2017; 19(1): 255.
[http://dx.doi.org/10.1186/s13075-017-1452-4] [PMID: 29166923]
[27]
Hahn D, Thomson PD, Kala U, Beale PG, Levin SE. A review of Takayasu’s arteritis in children in Gauteng, South Africa. Pediatr Nephrol 1998; 12(8): 668-75.
[http://dx.doi.org/10.1007/s004670050526] [PMID: 9811393]
[28]
Cilliers AM, Adams PE, Ntsinjana H, Kala U. Review of children with Takayasu’s arteritis at a Southern African tertiary care centre. Cardiol Young 2018; 28(9): 1129-35.
[http://dx.doi.org/10.1017/S1047951118000938] [PMID: 29978771]
[29]
Hong CY, Yun YS, Choi JY, et al. Takayasu arteritis in Korean children: Clinical report of seventy cases. Heart Vessels Suppl 1992; 7: 91-6.
[http://dx.doi.org/10.1007/BF01744551] [PMID: 1360979]
[30]
Clemente G, Hilário MO, Len C, et al. Brazilian multicenter study of 71 patients with juvenile-onset Takayasu’s arteritis: Clinical and angiographic features. Rev Bras Reumatol Engl Ed 2016; 56(2): 145-51.
[http://dx.doi.org/10.1016/j.rbre.2016.01.004] [PMID: 27267528]
[31]
Sahin S, Hopurcuoglu D, Bektas S, et al. Childhood-onset Takayasu arteritis: A 15-year experience from a tertiary referral center. Int J Rheum Dis 2019; 22(1): 132-9.
[http://dx.doi.org/10.1111/1756-185X.13425] [PMID: 30397997]
[32]
Fan L, Zhang H, Cai J, et al. Clinical course and prognostic factors of childhood Takayasu’s arteritis: Over 15-year comprehensive analysis of 101 patients. Arthritis Res Ther 2019; 21(1): 31.
[http://dx.doi.org/10.1186/s13075-018-1790-x] [PMID: 30670069]
[33]
Feng Y, Tang X, Liu M, Zhou J, Zhao X, Li Q. Clinical study of children with Takayasu arteritis: A retrospective study from a single center in China. Pediatr Rheumatol Online J 2017; 15(1): 29.
[http://dx.doi.org/10.1186/s12969-017-0164-2] [PMID: 28416004]
[34]
Cakar N, Yalcinkaya F, Duzova A, et al. Takayasu arteritis in children. J Rheumatol 2008; 35(5): 913-9.
[PMID: 18381778]
[35]
Turanlı ET, Karacan I, Esatlioglu S, et al. THU0005 Whole genome linkage and exome sequencing analyses in takayasu arteritis families. BMJ Publishing Group Ltd. 2018.
[36]
Jeeva I, Sajid J, Ali O, Bonthron DT, Frossard PM. Atypical Takayasu arteritis: a family with five affected siblings. Med Sci Monit 2007; 13(8): CS101-5.
[PMID: 17660729]
[37]
Sahin Z, Bıcakcıgil M, Aksu K, et al. Takayasu’s arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey. Arthritis Res Ther 2012; 14(1): R27.
[http://dx.doi.org/10.1186/ar3730] [PMID: 22309845]
[38]
Saruhan-Direskeneli G, Hughes T, Aksu K, et al. Identification of multiple genetic susceptibility loci in Takayasu arteritis. Am J Hum Genet 2013; 93(2): 298-305.
[http://dx.doi.org/10.1016/j.ajhg.2013.05.026] [PMID: 23830517]
[39]
Sandhya P, Danda S, Danda D, et al. Tumour necrosis factor (TNF)-α-308 gene polymorphism in Indian patients with Takayasu’s arteritis - a pilot study. Indian J Med Res 2013; 137(4): 749-52.
[PMID: 23703343]
[40]
Gravanis MB. Giant cell arteritis and Takayasu aortitis: Morphologic, pathogenetic and etiologic factors. Int J Cardiol 2000; 75(Suppl. 1): S21-33.
[http://dx.doi.org/10.1016/S0167-5273(00)00184-4] [PMID: 10980333]
[41]
Jain S, Sharma N, Singh S, Bali HK, Kumar L, Sharma BK. Takayasu arteritis in children and young indians. Int J Cardiol 2000; 75(Suppl. 1): S153-7.
[http://dx.doi.org/10.1016/S0167-5273(00)00180-7] [PMID: 10980355]
[42]
Takasaki J, Manabe T, Morino E, et al. Sensitivity and specificity of QuantiFERON-TB Gold Plus compared with QuantiFERON-TB Gold In-Tube and T-SPOT.TB on active tuberculosis in Japan. JIC 2018; 24(3): 188-92.
[43]
Arnaud L, Haroche J, Mathian A, Gorochov G, Amoura Z. Pathogenesis of Takayasu’s arteritis: A 2011 update. Autoimmun Rev 2011; 11(1): 61-7.
[http://dx.doi.org/10.1016/j.autrev.2011.08.001] [PMID: 21855656]
[44]
Park MC, Lee SW, Park YB, Lee SK. Serum cytokine profiles and their correlations with disease activity in Takayasu’s arteritis. Rheumatology (Oxford) 2006; 45(5): 545-8.
[http://dx.doi.org/10.1093/rheumatology/kei266] [PMID: 16352633]
[45]
Moriwaki R, Numano F. Takayasu arteritis: follow-up studies for 20 years. Heart Vessels Suppl 1992; 7: 138-45.
[http://dx.doi.org/10.1007/BF01744560] [PMID: 1360960]
[46]
Dagna L, Salvo F, Tiraboschi M, et al. Pentraxin-3 as a marker of disease activity in Takayasu arteritis. Ann Intern Med 2011; 155(7): 425-33.
[http://dx.doi.org/10.7326/0003-4819-155-7-201110040-00005] [PMID: 21969341]
[47]
Salvarani C, Cantini F, Boiardi L, Hunder GG. Laboratory investigations useful in giant cell arteritis and Takayasu’s arteritis. Clin Exp Rheumatol 2003; 21(6)(Suppl. 32): S23-8.
[PMID: 14740424]
[48]
Hoffman GS, Ahmed AE. Surrogate markers of disease activity in patients with Takayasu arteritis. A preliminary report from The International Network for the Study of the Systemic Vasculitides (INSSYS). Int J Cardiol 1998; 66(Suppl. 1): S191-4.
[http://dx.doi.org/10.1016/S0167-5273(98)00181-8] [PMID: 9951819]
[49]
Maksimowicz-McKinnon K, Bhatt DL, Calabrese LH. Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers. Curr Opin Rheumatol 2004; 16(1): 18-24.
[http://dx.doi.org/10.1097/00002281-200401000-00005] [PMID: 14673384]
[50]
Noris M, Daina E, Gamba S, Bonazzola S, Remuzzi G. Interleukin-6 and RANTES in Takayasu arteritis: A guide for therapeutic decisions? Circulation 1999; 100(1): 55-60.
[http://dx.doi.org/10.1161/01.CIR.100.1.55] [PMID: 10393681]
[51]
Sun Y, Ma L, Yan F, et al. MMP-9 and IL-6 are potential biomarkers for disease activity in Takayasu’s arteritis. Int J Cardiol 2012; 156(2): 236-8.
[http://dx.doi.org/10.1016/j.ijcard.2012.01.035] [PMID: 22330005]
[52]
Cieślik P, Hrycek A. Long pentraxin 3 (PTX3) in the light of its structure, mechanism of action and clinical implications. Autoimmunity 2012; 45(2): 119-28.
[http://dx.doi.org/10.3109/08916934.2011.611549] [PMID: 21988562]
[53]
Yamato M, Lecky JW, Hiramatsu K, Kohda E. Takayasu arteritis: Radiographic and angiographic findings in 59 patients. Radiology 1986; 161(2): 329-34.
[http://dx.doi.org/10.1148/radiology.161.2.2876459] [PMID: 2876459]
[54]
Khandelwal N, Kalra N, Garg MK, et al. Multidetector CT angiography in Takayasu arteritis. Eur J Radiol 2011; 77(2): 369-74.
[http://dx.doi.org/10.1016/j.ejrad.2009.08.001] [PMID: 19720487]
[55]
Direskeneli H. Clinical assessment in Takayasu's arteritis: Major challenges and controversies. Clin Exp Rheumatol 2017; 35(Suppl 103)(1): 189-93.
[56]
Choe YH, Han BK, Koh EM, Kim DK, Do YS, Lee WR. Takayasu’s arteritis: assessment of disease activity with contrast-enhanced MR imaging. AJR Am J Roentgenol 2000; 175(2): 505-11.
[http://dx.doi.org/10.2214/ajr.175.2.1750505] [PMID: 10915704]
[57]
Mavrogeni S, Dimitroulas T, Chatziioannou SN, Kitas G. The role of multimodality imaging in the evaluation of Takayasu arteritis. Semin Arthritis Rheum 2013; 42(4): 401-12.
[http://dx.doi.org/10.1016/j.semarthrit.2012.07.005] [PMID: 22920236]
[58]
Mavrogeni S, Manoussakis MN. Myocarditis and subclavian stenosis in Takayasu arteritis. Int J Cardiol 2011; 148(2): 223-4.
[http://dx.doi.org/10.1016/j.ijcard.2009.05.008] [PMID: 19482365]
[59]
Mavrogeni S, Servos G, Smerla R, et al. Cardiovascular involvement in pediatric systemic autoimmune diseases: The emerging role of noninvasive cardiovascular imaging. Inflamm Allergy Drug Targets 2015; 13(6): 371-81.
[http://dx.doi.org/10.2174/1871528114999150317150050] [PMID: 25778740]
[60]
Ozen S, Pistorio A, Iusan SM, et al. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria. Ann Rheum Dis 2010; 69(5): 798-806.
[http://dx.doi.org/10.1136/ard.2009.116657] [PMID: 20413568]
[61]
Hata A, Noda M, Moriwaki R, Numano F. Angiographic findings of Takayasu arteritis: New classification. Int J Cardiol 1996; 54(Suppl.): S155-63.
[http://dx.doi.org/10.1016/S0167-5273(96)02813-6] [PMID: 9119518]
[62]
Morishita KA, Rosendahl K, Brogan PA. Familial Takayasu arteritis - a pediatric case and a review of the literature. Pediatr Rheumatol Online J 2011; 9: 6.
[http://dx.doi.org/10.1186/1546-0096-9-6] [PMID: 21288360]
[63]
Sharma S, Kamalakar T, Rajani M, Talwar KK, Shrivastava S. The incidence and patterns of pulmonary artery involvement in Takayasu’s arteritis. Clin Radiol 1990; 42(3): 177-81.
[http://dx.doi.org/10.1016/S0009-9260(05)81929-4] [PMID: 1976467]
[64]
Stern S, Clemente G, Reiff A, Ramos MP, Marzan KA, Terreri MT. Treatment of Pediatric Takayasu arteritis with infliximab and cyclophosphamide: Experience from an American-Brazilian cohort study. J Clin Rheumatol 2014; 20(4): 183-8.
[http://dx.doi.org/10.1097/RHU.0000000000000106] [PMID: 24847743]
[65]
Osman M, Pagnoux C, Dryden DM, Storie D, Yacyshyn E. The role of biological agents in the management of large vessel vasculitis (LVV): A systematic review and meta-analysis. PLoS One 2014; 9(12): e115026.
[http://dx.doi.org/10.1371/journal.pone.0115026] [PMID: 25517966]
[66]
Hellmich B, Agueda A, Monti S, et al. 2018 Update of the EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis 2020; 79(1): 19-30.
[http://dx.doi.org/10.1136/annrheumdis-2019-215672] [PMID: 31270110]
[67]
Giordano JM. Surgical treatment of Takayasu’s arteritis. Int J Cardiol 2000; 75(Suppl. 1): S123-8.
[http://dx.doi.org/10.1016/S0167-5273(00)00179-0] [PMID: 10980350]
[68]
Liang P, Tan-Ong M, Hoffman GS. Takayasu’s arteritis: vascular interventions and outcomes. J Rheumatol 2004; 31(1): 102-6.
[PMID: 14705227]
[69]
Liang P, Hoffman GS. Advances in the medical and surgical treatment of Takayasu arteritis. Curr Opin Rheumatol 2005; 17(1): 16-24.
[http://dx.doi.org/10.1097/01.bor.0000146607.65808.37] [PMID: 15604900]
[70]
Sivakumar M, Misra R, Bacon P. Op14. The Indian perspective of Takayasu arteritis and development of a Disease Extent Index (DEI. Tak) to assess Takayasu arteritis. Rheumatology 2005; 44(Suppl. 3): iii6-7.
[http://dx.doi.org/10.1093/rheumatology/keh739]
[71]
Misra R, Danda D, Rajappa SM, et al. Development and initial validation of the Indian takayasu clinical activity score (ITAS2010). Rheumatology (Oxford) 2013; 52(10): 1795-801.
[http://dx.doi.org/10.1093/rheumatology/ket128] [PMID: 23594468]
[72]
Bacon P, Sivakumar R, Danda D, et al. Vasculitis assessment and Takayasu aorto-arteritis. Indian J Rheumatol 2012; 7(3): 153-8.
[http://dx.doi.org/10.1016/j.injr.2012.07.001]

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