Title:DCE-MRI Performance in Triple Negative Breast Cancers: Comparison
with Non-Triple Negative Breast Cancers
Volume: 18
Author(s): Hang Chen, Yu Min, Ke Xiang, Jialin Chen and Guobing Yin*
Affiliation:
- Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, No.74,
Linjiang Rd, Yuzhong Dist, Chongqing 404100, P.R. China
Keywords:
Dynamic contrast enhanced magnetic resonance imaging, triple negative breast cancer, comparison, molecular subtype, imaging feature, prediction.
Abstract:
Background: Triple negative breast cancers are considered the worst prognosis in breast
cancer. Dynamic contrast enhanced magnetic resonance imaging has been widely used in the diagnosis
of breast cancer since it is more sensitive to breast cancer. However, few studies report the MRI characteristics
of triple negative breast cancers.
Objective: The study aimed to evaluate the imaging finding in triple negative breast cancers compared
with non-TNBC and attempt to predict it.
Methods: 223 patients with a preoperative diagnosis of breast cancer were enrolled in the study. Dynamic
contrast enhanced magnetic resonance imaging was performed before being diagnosed with
breast cancer, and histopathological assessment was confirmed after biopsy or operation. The patients
were divided into 2 groups based on immunohistochemistry, namely the triple negative breast cancers
or non-triple negative breast cancers.
Results: The 2 groups demonstrated significant differences regarding the tumor size, margin, outline,
burr sign, enhancement, inverted nipple(P<0.05). A multivariate logistic regression analysis was performed
to further validate the association of these features, however, only margin [odds ratio (OR),
0.038; 95% confidence interval (CI), 0.014-0.100; <0.001], outline [odds ratio (OR), 0.039; 95% confidence
interval (CI), 0.008-0.200; <0.001], burr sign [odds ratio (OR), 2.786; 95% confidence interval
(CI), 1.225-6.333; 0.014], and enhancement [odds ratio (OR), 0.131; 95% confidence interval (CI),
0.037-0.457; P=0.001] were associated with TNBC.
Conclusion: The results indicated that the specific dynamic contrast enhanced magnetic resonance
imaging features can predict pathological results, with a consequent prognostic value.
