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Review Article

小檗碱的抗癌机制:一种治疗胶质母细胞瘤的良好选择

卷 29, 期 26, 2022

发表于: 06 April, 2022

页: [4507 - 4528] 页: 22

弟呕挨: 10.2174/0929867329666220224112811

价格: $65

摘要

最典型的恶性脑肿瘤，多形性胶质母细胞瘤（GBM），尽管采用了密集的多模式干预，似乎有一个严峻的结果。文献表明，具有生物活性的植物分子可能通过调节多种信号通路发挥抗癌特性。小檗碱是一种异喹啉生物碱，在药理上有多种应用，可对抗癌症等严重疾病。机制上，抑制细胞增殖和侵袭，抑制肿瘤血管生成，诱导细胞凋亡。黄连素对GBM的抗肿瘤作用日益被人们所认识。这篇综述揭示了黄连素在各种癌症中的调控信号机制，提出了其作为GBM治疗剂的潜在作用。

关键词: 多形性胶质母细胞瘤，植物分子，小檗碱，自噬，凋亡，恶性脑肿瘤。

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