Title:Neonatal Arterial Ischaemic Stroke: Advances in Pathologic Neural Death,
Diagnosis, Treatment, and Prognosis
Volume: 20
Issue: 12
Author(s): Yang He, Junjie Ying, Jun Tang*, Ruixi Zhou, Haibo Qu, Yi Qu and Dezhi Mu*
Affiliation:
- Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
- Key Laboratory
of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu,
China
- Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
- Key Laboratory
of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu,
China
Keywords:
NAIS, pathology, diagnosis, treatment, prognosis, therapeutic targets.
Abstract: Neonatal arterial ischaemic stroke (NAIS) is caused by focal arterial occlusion and often
leads to severe neurological sequelae. Neural deaths after NAIS mainly include necrosis, apoptosis,
necroptosis, autophagy, ferroptosis, and pyroptosis. These neural deaths are mainly caused by upstream
stimulations, including excitotoxicity, oxidative stress, inflammation, and death receptor
pathways. The current clinical approaches to managing NAIS mainly focus on supportive treatments,
including seizure control and anticoagulation. In recent years, research on the pathology, early
diagnosis, and potential therapeutic targets of NAIS has progressed. In this review, we summarise
the latest progress of research on the pathology, diagnosis, treatment, and prognosis of NAIS and
highlight newly potential diagnostic and treatment approaches.
