Title:Antidepressant Prescription for Major Depressive Disorder: Results from
a Population-Based Study in Italy
Volume: 20
Issue: 12
Author(s): Bernardo Dell'Osso, Marco Di Nicola, Riccardo Cipelli, Ilaria Peduto, Anna Cristina Pugliese, Maria Salvina Signorelli, Antonio Ventriglio and Giovanni Martinotti*
Affiliation:
- Department of Neuroscience, Imaging and Clinical
Sciences, University "G. d'Annunzio" of Chieti - Pescara, Chieti, Italy
- Psychopharmacology, Drug Misuse & Novel
Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hertfordshire,
UK
Keywords:
Antidepressant, major depressive disorder, primary care, population-based, longitudinal, Real World study, prescribing pattern.
Abstract:
Objectives: There is limited evidence about the factors influencing antidepressant (AD)
prescription for the treatment of major depressive disorder (MDD) in Real World clinical practice in
Italy. In this retrospective, population-based study, we set out to describe a patient cohort initiated
on AD treatment for MDD and investigate the possible predictors of different AD prescriptions in
the primary care setting.
Methods: Patients with a diagnosis of MDD who received an initial prescription of one of 11 selected
ADs between 1-Apr-2017 and 31-Mar-2019 (index date) were identified from primary care electronic
medical records in the Longitudinal Patient Database. Patients prescribed ≥1 AD in the 12
months before the index date were excluded. Results were stratified by AD molecule. Multivariable
logistic regression models estimated the association between patients’ demographic, clinical factors,
and choice of AD molecule.
Results: The study cohort comprised 8,823 patients (67.1% female; mean age 61.6 years). Previous
AD treatments (prescribed in the 10 years before the index date) had been received by 46.6% of patients
(non-naïve patients). The most commonly reported psychiatric and medical comorbidities reported
in the 12 months before the index date were anxiety (8.4%) and hypertension (41.9%), respectively.
Patients’ age was a significant predictor of AD molecule prescribed at index date in eight
of the 11 molecules investigated, while patients’ gender influenced clinician prescribing bupropion,
citalopram, fluoxetine, fluvoxamine, sertraline, and vortioxetine.
Conclusion: Results from this Real World study provide useful information for clinicians on the
clinical factors influencing AD prescription in patients treated for MDD in primary care.
