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Review Article

电化学检测肝癌生物标志物的核酸适配体和新型生物受体

卷 29, 期 25, 2022

页: [4363 - 4390] 页: 28

弟呕挨: 10.2174/0929867329666220222113707

价格: $65

摘要

肝细胞癌是一种死亡率高、发病率高的恶性肿瘤。这种疾病的早期发现可以帮助提高生存率和患者的整体利益。这种疾病的非侵入性诊断策略是最重要的。在这个范围内，检测肝细胞癌的生物标志物可以提供一个有用的诊断工具。核酸适配体是一种短的单链DNAs或RNAs，可以特异性结合选定的分析物，并作为可用于电极功能化的伪生物识别元件。此外，其他类型的DNA序列也可以用来构建用于肝细胞癌生物标志物定量的DNA生物传感器。在此，我们分析了用于检测肝细胞癌生物标志物（如micro- RNAs、长链非编码 RNAs、外泌体、循环肿瘤细胞和蛋白质）的适体传感器和 DNA 生物传感器的最新示例。文献数据进行了比较批判性的讨论，突出了在诊断中使用电化学生物传感器的优势，以及使用纳米材料和生物成分在电极功能化以提高灵敏度和选择性。

关键词: 肝细胞癌（HCC），适配体，生物标志物，电化学生物传感器，DNA序列，miRNAs。

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