Title:Recent Development in the Synthesis of Thiazoles
Volume: 19
Issue: 6
Author(s): Dau Xuan Duc*Nguyen Thi Chung
Affiliation:
- Department of Chemistry, Vinh University, Vinh City, Nghe An Province, Vietnam
Keywords:
α-haloketones, thioamides, acetophenones, isocyanides, thioureas, Hantzsch cyclization, thiosemicarbazides, thiazoles.
Abstract:
Background: Thiazole-containing compounds are widely found in natural products as
well as synthetic sources. Many thiazole-based compounds possess a broad spectrum of
bioactivities, and some of them are well-known drugs in the markets. The use of thiazole
derivatives in other fields such as organic materials, cosmetics, and organic synthesis has also
been widely reported. Due to a wide range of applicability, the synthesis of thiazole-containing
compounds has attracted extensive interest from chemists, and many studies in the synthesis of
thiazole skeleton have been reported recently.
Objective: This review article will discuss recent studies in the synthesis of thiazoles (from2012).
Besides the well-established Hantzsch thiazole synthesis, a large number of novel methods have
been developed for the synthesis of thiazole derivatives. In most cases, reaction mechanisms have
also been described.
Conclusion: The synthesis of thiazole derivatives has drawn great attention from chemists, and
many studies in the synthesis of these heterocycles have been reported recently. The classical
method, the Hantzsch thiazole synthesis has received great research interest from chemists.
Moreover, many new methods have been established to synthesize thiazole-derived compounds.
Unquestionably, more and more approaches to access thiazole skeleton will appear in the
literature. The application of well-established thiazole synthesis methods to the synthesis of
drugs, organic materials, and natural products will almost certainly be studied.
