Title:Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland
Disorders
Volume: 29
Issue: 16
Author(s): Farzaneh Shakeri, Bahram Bibak, Mohammad Reza Safdari, Zakieh Keshavarzi, Tannaz Jamialahmadi, Thozhukat Sathyapalan*Amirhossein Sahebkar*
Affiliation:
- Department of Academic Diabetes, Endocrinology and
Metabolism, Hull York Medical School, University of Hull, Hull, UK
- Applied Biomedical Research Center,
Mashhad University of Medical Sciences, Mashhad, Iran
- Biotechnology Research Center, Pharmaceutical
Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
- Department of
Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
- School of
Medicine, The University of Western Australia, Perth, Australia
Keywords:
Curcumin, thyroid gland, molecular mechanisms, hormones, thyrotropin, pituitary gland.
Abstract: There is growing literature on the positive therapeutic potentials of curcumin.
Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa.
Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The
role of curcumin in thyroid gland disorders has been demonstrated by its effects on various
biological pathways, including anti-inflammatory, antioxidant, anti-proliferative,
apoptosis, angiogenesis, cell cycle and metastasis. In this paper, we have reviewed the recent
literature on curcumin applications for thyroid dysfunction, including hyperthyroidism
and hypothyroidism, and discussed the molecular mechanisms of these effects.
This review aims to summarize the wealth of research related to the therapeutic effect of
curcumin on the thyroid gland.
