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Current Pediatric Reviews

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ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

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Review Article

Necrotizing Enterocolitis: Clinical Features, Histopathological Characteristics, and Genetic Associations

Author(s): Akhil Maheshwari*, Terri M. Traub, Parvesh M. Garg, Yahya Ethawi and Giuseppe Buonocore

Volume 18, Issue 3, 2022

Published on: 30 March, 2022

Page: [210 - 225] Pages: 16

DOI: 10.2174/1573396318666220204113858

Price: $65

Open Access Journals Promotions 2
Abstract

Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis seen in premature infants. Although the etiopathogenesis of NEC is unclear, genetic factors may alter a patient's susceptibility, clinical course, and outcomes. This review draws from existing studies focused on individual genes and others based on microarray-based high-throughput discovery techniques. We have included evidence from our own studies and from an extensive literature search in the databases PubMed, EMBASE, and Scopus. To avoid bias in the identification of studies, keywords were short-listed a priori from anecdotal experience and PubMed’s Medical Subject Heading (MeSH) thesaurus.

Keywords: Necrotizing enterocolitis, clinical, histopathology, genetic, genomic, microarray, necrosis.

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