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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties

Author(s): Ban-Feng Ruan, Qing-Lei Guo, Qing-Shan Li, Lu-Zhi Li, Girdhar Singh Deora* and Ben-Guo Zhou*

Volume 22, Issue 7, 2022

Published on: 02 March, 2022

Page: [578 - 599] Pages: 22

DOI: 10.2174/1568026622666220202123651

Price: $65

Abstract

The oxadiazole core is considered a privileged moiety in many medicinal chemistry applications. The oxadiazole class includes 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,5-oxadiazole. Compounds bearing an oxadiazole ring show a wide range of biological activities, such as anticancer, antibacterial, anti-inflammatory, anti-malarial, and insecticidal properties. Among oxadiazoles, the 1,3,4-oxadiazole has been the most widely explored moiety in medicinal chemistry research. This review is primarily focused on the anticancer, antibacterial, and anti-inflammatory activities of compounds containing 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,5-oxadiazole reported in the last five years.

Keywords: Heterocyclic compounds, Oxadiazole, Anticancer, Antibacterial, Anti-inflammatory, SAR.

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