Single Nucleotide Polymorphisms in Neonatal Necrotizing Enterocolitis

Keyur   T.   Donda; Benjamin   A.   Torres; Minesh      Khashu; Akhil      Maheshwari
doi:10.2174/1573396318666220117091621
Abstract

The etiopathogenesis of necrotizing enterocolitis (NEC) remains unclear, but increasing information suggests that the risk and severity of NEC may be influenced by single nucleotide polymorphisms in many genes. In this article, we have reviewed gene variations that have either been specifically identified in NEC or have been noted in other inflammatory bowel disorders with similar histopathological abnormalities. We present evidence from our own peer-reviewed laboratory studies and data from an extensive literature search in the databases PubMed, EMBASE, and Scopus. To avoid bias in the identification of existing studies, search keywords were short-listed both from our own studies and from PubMed’s Medical Subject Heading (MeSH) thesaurus.
Keywords: Single nucleotide polymorphism, necrotizing enterocolitis, neonates, genetic predisposition, spontaneous intestinal perforation, inherited disease.
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DOI https://dx.doi.org/10.2174/1573396318666220117091621	Print ISSN 1573-3963
Publisher Name Bentham Science Publisher	Online ISSN 1875-6336
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Single Nucleotide Polymorphisms in Neonatal Necrotizing Enterocolitis

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