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Review Article

靶向mTOR信号在2型糖尿病和糖尿病并发症中的作用

卷 23, 期 7, 2022

发表于: 21 February, 2022

页: [692 - 710] 页: 19

弟呕挨: 10.2174/1389450123666220111115528

价格: $65

摘要

雷帕霉素（rapamycin, mTOR）的作用靶点是细胞代谢和生长的关键调控因子。mTOR以两种不同的多蛋白复合物mTORC1和mTORC2的形式整合细胞能量、营养和激素信号，调节细胞代谢稳态。在2型糖尿病（T2DM）中，病理条件和末端器官并发症可归因于异常的mTOR。大量证据表明，mTORC1-p70S6激酶1 （S6K1）和mtorc2蛋白激酶B （AKT）这两种mTORC1-p70S6激酶信号通路在胰岛素敏感性中发挥关键作用，它们的功能障碍有助于T2DM的发生。本文综述了我们目前对mTOR信号通路在T2DM及其相关并发症中的作用的认识，以及mTOR抑制剂在T2DM治疗中的潜在应用。

关键词: mTORC1, mTORC2, 2型糖尿病，糖尿病并发症，mTOR抑制剂，关键调节剂。

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图形摘要

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