Title:Molecules Containing Cyclobutyl Fragments as Therapeutic Tools: A
Review on Cyclobutyl Drugs
Volume: 29
Issue: 23
Author(s): Shuang Ren, Fei Pan, Wen Zhang and Guo-Wu Rao*
Affiliation:
- College of Pharmaceutical Science, Zhejiang University of Technology, and Institute of Drug Development
& Chemical Biology, Zhejiang University of Technology, Hangzhou 310014, P.R. China
Keywords:
Cyclobutyl drugs, platinum, anticancer drugs, cancer, structure-activity relationship, approved drugs, kinase inhibitor.
Abstract: In recent years, cyclobutyl has become more influential in the field of drug design.
Its unique four-membered ring structure is not only a useful intermediate for the
synthesis of biomedical candidate materials but also an indispensable framework for drug
design and application. According to the therapeutic field, cyclobutyl drugs are roughly
divided into tumor and cancer drugs, nervous system drugs, analgesics, antiviral drugs,
and gastrointestinal drugs. Among them, platinum-based anticancer drugs containing cyclobutyl
fragments have achieved remarkable success in the treatment of cancer, bringing
new hope for the development of more cyclobutyl drugs. This article provides details of
the research progress of the structure types, structure-activity relationships, targets, and
mechanisms of cyclobutyl drugs that have been on the market or are in the clinical stage
and provides ideas for the discovery and synthesis of novel cyclobutyl-containing drugs.
