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Review Article

人血小板非编码RNA在心血管疾病中的作用

卷 29, 期 19, 2022

发表于: 03 February, 2022

页: [3420 - 3444] 页: 25

弟呕挨: 10.2174/0929867329666211230104955

价格: $65

摘要

心血管疾病(CVD)是世界上主要的死亡原因。近年来，已经开展了大量涉及转录组学方法的遗传学研究，旨在详细了解该疾病和开发新的治疗策略。对血小板的研究越来越多，因为血小板与CVD有关，因为它们能够释放影响各种途径的调节分子。血小板向血浆分泌超过500种不同的分子，包括大量的非编码(nc)RNA(miRNA、lncRNA或circRNA)。这些ncRNA对应于98%的未被翻译成蛋白质的转录本，因为它们在生理和疾病中是重要的调节因子。因此，miRNAs可以通过碱基配对相互作用将蛋白质复合物引导到mRNA，从而导致翻译阻断或/和转录降解。这些lncRNA通过与转录因子结合，通过不同的机制发挥作用。最后，环状RNA作为miRNA的调节因子，干扰其作用。血小板分泌的ncRNA的曲目和/或数量的改变可以触发CVD和其他疾病。ncRNA可以作为疾病的有效生物标志物，或由于其参与疾病而作为治疗靶点。在这篇综述中，我们将重点讨论由血小板分泌的最重要的ncRNA(9miRNA，9lncRNA和5circRNA)，它们与CVD的关系，以及这些ncRNA对CVD风险的贡献，以更好地理解人血小板ncRNA与CVD之间的关系。

关键词: 心血管疾病，miRNA，lncRNA，环状cRNA，血小板，环状RNA。

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