Title:Whole-Brain Volume CT Angiography can Effectively Detect Early Ischemic
Cerebrovascular Diseases
Volume: 18
Author(s): Shi-Feng Xiang, Jun-Tao Li, Su-Jun Yang, Fang-Fang Ding, Wei-Wei Wang, Shuang Huo, Jian-Wen Li, Wei-Yong Zhang and Bu-Lang Gao*
Affiliation:
- Department of Radiology, Handan City Central Hospital, Handan, 056001 Hebei Province, China
Keywords:
Ischemic cerebrovascular disease, 320-row volume CT, perfusion imaging, cerebral hemodynamics, arterial stenosis, angiography.
Abstract:
Objective: To investigate the role of whole-brain volume computed tomography (CT)
perfusion in assessing early ischemic cerebrovascular diseases.
Materials and Methods: Seventy-two patients with early ischemic cerebrovascular diseases who
had undergone routine CT scan and 320-row volume CT whole-brain perfusion imaging within 8 h
after admission were retrospectively enrolled in this one-center case-sectional study. The perfusion
parameters of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT),
time to peak (TTP), and dynamic CT angiogram (4D-CTA) were obtained and analyzed.
Results: Among 72 patients, 29 cases with 37 cerebral ischemic lesions were found in plain CT
scan, whereas 51 cases with 76 lesions were found in whole-brain CT perfusion, with 30.6% more
patients being detected. The CBF value was significantly lower in the abnormal than normal corresponding
perfusion area in the healthy hemisphere (P<0.05), while the MTT and TTP values were
significantly higher in the abnormal than the normal corresponding area (P<0.05). 4D-CTA image
suggested that 59 cases had different degrees of stenosis or occlusion, including 11 mild, 18 moderate,
21 severe, and 9 occlusive cases. Four-D-CTA imaging could detect significantly (P<0.05)
more patients with abnormal perfusion in severe cerebral vascular stenosis or occlusion than those
with no, mild or moderate stenosis (93.33% vs. 16.67%) (P<0.05). The stenosis of intracranial and
carotid arteries was positively correlated with MTT and TTP values (P<0.05).
Conclusion: Whole-brain volume CT angiography can comprehensively display early cerebral ischemic
lesions, cerebral blood perfusion status, and cerebral vascular stenosis, providing valuable
information for early detection of ischemic cerebral diseases and appropriate treatment planning.
