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General Review Article

左旋肉碱：寻找脓毒症治疗的新治疗策略

卷 29, 期 18, 2022

发表于: 14 January, 2022

页: [3300 - 3323] 页: 24

弟呕挨: 10.2174/0929867328666211117092345

价格: $65

摘要

在这篇综述中，我们讨论了肉碱的生物学靶点及其对免疫功能的影响，以及补充l-肉碱如何帮助危重患者。左旋肉碱是一种有效的抗氧化剂。在长期重症监护病房(ICU)住院中观察到l-肉碱消耗，而补充l-肉碱在促进健康和调节免疫方面有有益作用。它对线粒体摄取脂肪酸至关重要。肉碱通过抑制泛素-蛋白酶体系统，下调心脏组织中的顶端受体，降低脂肪酸的β-氧化，可降低脓毒性休克中血管升压药的需求，改善这组患者的临床预后。我们还回顾了一些旨在评估l-肉碱在脓毒症/脓毒症休克治疗中的有益作用的动物和临床研究。需要更多的临床数据来评估l-肉碱补充的最佳每日剂量和持续时间。

关键词: 左旋肉碱，脓毒症，脓毒性休克，危重症，重症监护，抗氧化剂。

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