Title:Perspective on the Role of Four Beta-blockers in Heart Failure
Volume: 17
Issue: 2
Author(s): Asim Ahmed Elnour Ahmed*
Affiliation:
- Clinical Pharmacy Program, College of Pharmacy, Al Ain University, Abu Dhabi Campus, UAE
Keywords:
Bisoprolol, carvedilol, metoprolol succinate, nebivolol, heart failure, beta blocker.
Abstract:
Background: The current recommendations of the American College of Cardiology/
American Heart Association and a previous Bayesian analysis clearly show a mortality benefit with
the use of β- blockers in chronic HF, especially for bisoprolol, carvedilol, and sustained-release
metoprolol succinate.
Objective: The main objective was to report the evidence on the use of the afore-mentioned β-blockers
in subjects with heart failure and to characterize the stages of heart failure in response to the four different
β-blockers. Furthermore, it shed light on the patient’s satisfaction and improved quality of life
using the afore-mentioned β-blockers in subjects with heart failure.
Methods: The current perspective presented the clinical outcomes, including hospitalization, morbidity,
mortality, patient’s satisfaction, and quality of life, of four beta (β)-blockers, namely bisoprolol,
carvedilol, metoprolol succinate, and nebivolol in different stages of heart failure.
Results: The use of these three agents should be recommended for all stable subjects with current or
previous symptoms of heart failure and heart failure with reduced ejection fraction unless there is any
contraindication. The fore-mentioned β-blockers (bisoprolol, carvedilol, and metoprolol succinate) can
be initiated early, even in stable and symptom-free (at rest) subjects with heart failure. β-blockers in
heart failure should be commenced at small doses and then titrated upward as tolerated to achieve the
desired clinical effects on heart rate and symptom control.
Conclusion: Cardiologists should weigh the benefit-risk in subjects with heart failure and other coexisting
cardiovascular problems such as atrial fibrillation and diabetes.
