Title:Long Non-Coding RNA GAS5 in Age-Related Diseases
Volume: 29
Issue: 16
Author(s): Yaqi Wang, Mengzhen Xue, Fangqi Xia, Leiqi Zhu, Dengke Jia, Yan Gao, Luoying Li, Yue Shi, Yuanyang Li, Silong Chen, Guangfu Xu and Chengfu Yuan*
Affiliation:
- College of Medical Science, China Three Gorges University, Yichang 443002, China
- Third-Grade Pharmacological
Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese
Medicine, Medical College of China Three Gorges, Yichang. Hubei 443002. China
Keywords:
lncRNAs , GAS5 , age-related diseases , atherosclerosis , type 2 diabetes mellitus , cancer.
Abstract: Aging refers to a natural process and a universal phenomenon in all cells, tissues,
organs, and the whole organism. Long non-coding RNAs (lncRNAs) are non-coding
RNAs with a length of 200 nucleotides. LncRNA growth arrest-specific 5 (lncRNA
GAS5) is often down-regulated in cancer. The accumulation of lncRNA GAS5 has been
found to be able to inhibit cancer growth, invasion, and metastasis while enhancing the
sensitivity of cells to chemotherapy drugs. LncRNA GAS5 can be a signaling protein,
which is specifically transcribed under different triggering conditions. Subsequently, it is
involved in signal transmission in numerous pathways as a signal node. LncRNA GAS5,
with a close relationship to multiple miRNAs, was suggested to be involved in the signaling
pathway under three action modes (i.e., signal, bait, and guidance). LncRNA GAS5
was found to be involved in different age-related diseases (e.g., rheumatoid arthritis, type
2 diabetes, atherosclerosis, osteoarthritis, osteoporosis, multiple sclerosis, cancer, etc.).
This study mainly summarized the regulatory effect exerted by lncRNA GAS5 on age-related
diseases.
