Title:Human Gut Microbiome: A New Frontier in Cancer Diagnostics & Therapeutics
Volume: 27
Issue: 45
Author(s): Vibha Rani*, Shivani Singhal, Kumkum Sharma, Rohan Vaid, Kanishka Aggarwal, Renu Bhadana, Radhika Agarwal and Neha Atale
Affiliation:
- Center for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida 201307, Uttar Pradesh,India
Keywords:
Cancer, therapeutics, gut microbiota, dysbiosis, prebiotics, probiotics, synbiotics, postbiotics, antibiotics.
Abstract: The field of oncology is vast and ever-growing. The present cancer therapeutics is continually exhibiting
various drawbacks, which opens the door for exploring better novel therapeutic techniques. One such
emerging technique is the manipulation of gut microbiota to induce a positive curative effect in the body. The
dynamic gut microbiota of our body houses an astonishing number of microorganisms, mainly bacteria. The balance
of the gut microbiota is essential for good health as imbalances may result in dysbiosis leading to various
diseases such as cancer. The gut microbiota can be manipulated by using prebiotics, probiotics, synbiotics, postbiotics,
and antibiotics for better therapeutic outcomes, as well as to improve the quality of life of patients undergoing
conventional cancer treatment. Administration of bacteria as a probiotic agent accompanied with prebiotics
obtained from a wide variety of herbs has been used effectively to enhance the treatment of various cancers.
Although the theoretical basis of Gut therapy can be ascertained, further clinical trials will be essential to
determine the scope and limitations fully. The present review provides a glimpse of conventional and novel cancer
therapeutics and their drawbacks, along with the role of the gut microbiome and its modulation to design
new pharmaceutics against cancer.
