Title:The Roles of Signaling Pathways in Cardiac Regeneration
Volume: 29
Issue: 12
关键词:
信号通路，心脏，再生，Wnt信号传导，缺口信号传导，VEGF信号传导，IGF-1信号传导。
摘要: In recent years, knowledge of cardiac regeneration mechanisms has dramatically
expanded. Regeneration can replace lost parts of organs, common among animal species.
The heart is commonly considered an organ with terminal development, which has
no reparability potential during post-natal life. However, some intrinsic regeneration capacity
has been reported for cardiac muscle, which opens novel avenues in cardiovascular
disease treatment. Different endogenous mechanisms have been studied for cardiac repairing
and regeneration in recent decades. Survival, proliferation, inflammation, angiogenesis,
cell-cell communication, cardiomyogenesis, and anti-aging pathways are the
most important mechanisms that have been studied in this regard. Several in vitro and animal
model studies focused on proliferation induction for cardiac regeneration reported
promising results. These studies have mainly focused on promoting proliferation signaling
pathways and demonstrated various signaling pathways such as Wnt, PI3K/Akt, IGF-
1, TGF-β, Hippo, and VEGF signaling cardiac regeneration. Therefore, in this review, we
intend to discuss the connection between different critical signaling pathways in cardiac
repair and regeneration.
