Title:The Application of Prodrug-based Drug Delivery Strategy in Anticancer Drugs
Volume: 21
Issue: 24
Author(s): Nanxin Liu, Qinhua Chen , Qingqing Zhang, Jin Wang, Ru Si, Jie Zhang and Xiaoyan Pan*
Affiliation:
- School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi’an, 710061,China
Keywords:
Drug delivery strategy, Anticancer drugs, Prodrug design, In situ concentration, Targeted drug delivery, Cytotoxic
agents.
Abstract: Cancer is the second leading cause of human death after cardiovascular disease, and the
most used drugs in clinics are cytotoxic agents. However, these drugs have some inherent disadvantages,
such as the risk of toxicity, low selectivity, poor solubility, and so on. To overcome these
shortcomings, a variety of drug delivery strategies based on prodrugs have been developed. The application
of drug delivery systems can optimize ADME properties of cytotoxic agents and improve
their selectivity at the target, thereby greatly enhancing the anticancer effect in clinics. At present, it
has become mainstream in drug design. This review systematically summarized the studies of prodrug-
based drug delivery systems over the past five to ten years, according to four aspects, solubility,
controlled release, in situ concentration, and targeting.
