Title:The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common
Cancers
Volume: 28
Issue: 7
Author(s): Qi Zhang, Yinxin Wu, Jinlan Chen, Fangshun Tan, Jie Mou, Zhuoying Du, Yuxuan Cai, Bei Wang and Chengfu Yuan*
Affiliation:
- College of Medical Science, China Three Gorges University, Yichang 443002, China
- Third-Grade Pharmacological Laboratory
on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang
443002, China
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang
443002, China
Keywords:
MBNL1, MBNL1-AS1, tumor, inhibitory factor, proliferation, migration, invasion.
Abstract:
Background: Muscle blind-like-proteins (MBNL) are a class of tissue-specific RNA metabolism regulators
that control pre-messenger RNA-splicing. Inactivation of MBNL can lead to myotonic dystrophy in
adults. MBNL is mainly expressed in skeletal muscle, neuron tissue, thymus, liver, and kidney and plays an important
role in the ultimate differentiation of muscle cells and neurons. MBNL1 is a member of the MBNL protein
family. The inactivation of MBNL1 protein is particularly important in the development of myotonic dystrophy
and can lead to cataract formation, abnormal muscle relaxation, cardiac and neurological dysfunction,
etc. The induction of MBNL1 in tumors is known to significantly inhibit tumor progression and thus significantly
prolong survival. MBNL1 antisense protein MBNL1-AS1 also plays an important role in tumor migration
and development.
Objective: This review reveals the role of MBNL1 and MBNL1-AS1 in the complex pathogenesis of many tumors,
which provide a new target for the treatment of tumors.
Methods: Correlated research are systematically retrieved via PubMed. In this review, the role of MBNL1 and
MBNL1- AS1 were analyzed.
Results: MBNL1 is down-regulated in breast cancer, leukemia, stomach cancer, esophageal cancer, glioma,
and Huntington's disease. The function of inhibiting tumor cell metastasis decreased. It is up-regulated in cervical
cancer and colorectal cancer, which can promote the development of tumor cells. Antisense protein MBNL1-
AS1 can inhibit tumor cell proliferation and metastasis in colorectal cancer, non-small cell lung cancer, and
gastric cancer.
Conclusion: MBNL1 is an important regulator of tumor metastasis and growth, which exhibits a promising
therapeutic target and can be further explored.
