Title:The Association between Tumor-associated Macrophages and Glioblastoma: A Potential Target for Therapy
Volume: 27
Issue: 46
Author(s): Arash Heidari, Pouya M. Sharif and Nima Rezaei*
Affiliation:
- Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran,Iran
Keywords:
Tumor-associated macrophages, tumor microenvironment, central nervous system tumors, glioblastoma multiforme, cancer immunotherapy,
cancer targeted therapy.
Abstract: Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults, causing
many deaths each year. The life expectancy of patients from the time of diagnosis does not exceed 15 months.
Tumoral cells are generally surrounded by a bed of tumor microenvironment (TME), composed of various components
such as different immune cells, stromal cells, and blood vessels. Previous studies on the treatment of
this tumor have generally focused on cancerous cells and, therefore, have introduced conventional therapies for
eradicating this tumor, including maximal safe surgery, chemotherapy with temozolomide (TMZ), and radiotherapy.
Despite treatment with this method, tumors almost always recur, and life expectancy has not increased
much. Recently, due to the discovery of the various roles of immune cells (including tumor-associated
macrophages or TAMs) in the pathogenesis of this disease, the path of studies has moved towards targeting
them as a treatment for glioblastoma. In this review, we aimed to investigate recent studies on the different
roles of TME components, the role of TAM in the pathogenesis, and novel methods that target TAMs, including
induction of TAM repolarization, inhibition of TAM-produced cytokines, and prohibition of immune system
suppression induced by TAMs. In this regard, various targets, including colony-stimulating factor-1 (CSF-
1) receptors, Nuclear factor-kappa B (NF-κB), or chemokine receptor (CXCR) pathways, are investigated.
