Title:Pharmacological Activities and Therapeutic Potential of Kaempferitrin in Medicine for the Treatment of Human Disorders: A Review of Medicinal Importance and Health Benefits
Volume: 21
Issue: 2
Author(s): Dinesh Kumar Patel*
Affiliation:
- Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences Naini, Prayagraj, 211007, Uttar Pradesh,India
Keywords:
Pharmacological activity, analytical techniques, apoptosis, cell proliferation, flavonoids, insulin-mimetic activity,
kaempferitrin.
Abstract:
Background: Herbal drugs and their derived phytochemicals are valuable for human beings
as a source of a vital component of food material and drugs. Flavonoids are naturally occurring
phytochemicals produced in plants through metabolisms, and they have anti-hyperlipidemia,
anti-inflammatory, anti-oxidant and anti-apoptotic activity. Flavonoids have been identified in
fruits, nuts, vegetables, seeds, stems, flowers, and tea. Kaempferol is a natural flavonoidal compound
present in edible plants such as apples, broccoli, strawberries, beans, grapefruit, propolis,
and medicinal plants such as Aloe vera, Ginkgo biloba, Rosmarinus officinalis, Crocus sativus L.,
Hypericum perforatum L. Kaempferol have anti-oxidant, anti-inflammatory, anti-apoptotic, proapoptotic,
cardio-protective and anti-cancer activities.
Methods: Glycosides of kaempferol such as kaempferitrin, also called kaempferol 3,7-dirhamnoside
are known to be more abundant than their flavonoid monomers in plants. Various literature
databases have been searched to collect all the scientific information of kaempferitrin in the present
investigation and analyzed in order to know the therapeutic benefit and biological potential of
kaempferitrin. Moreover, all the information has been presented here in two broad sections, i.e.,
pharmacological and analytical.
Results: From the analysis of all the collected and presented information, it was found that
kaempferitrin has potent insulin-mimetic potential and could be used for the treatment of diabetes
and related complications. However, it has also shown anti-oxidant, anti-inflammatory, anti-convulsant,
anti-osteoporotic, anti-depressant, anthelmintic, immunostimulatory, and natriuretic properties
and inhibits cell proliferation and apoptosis. Kaempferitrin also improves the meat quality of
broiler chickens.
Conclusion: The presented information in this work will be valuable to justify the biological importance
and therapeutic potential of kaempferitrin in the scientific field.
