Title:Ferroptosis: A Trusted Ally in Combating Drug Resistance in Cancer
Volume: 29
Issue: 1
关键词:
铁凋亡，擦除剂，癌症，耐药性，顺铂，纳米治疗。
摘要: Ferroptosis, which is an iron-dependent, non-apoptotic cell death mechanism,
has recently been proposed as a novel approach in cancer treatment. Bearing distinctive
features and its exclusive mechanism have put forward the potential therapeutic benefit
of triggering this newly discovered form of cell death. Numerous studies have indicated
that apoptotic pathways are often deactivated in resistant cells, leading to a failure in therapy.
Hence, alternative strategies to promote cell death are required. Mounting evidence
suggests that drug-resistant cancer cells are particularly sensitive to ferroptosis. Given
that cancer cells consume a higher amount of iron than healthy ones, ferroptosis not only
stands as an excellent alternative to trigger cell death and reverse drug-resistance, but also
provides selectivity in therapy. This review focuses specifically on overcoming drugresistance
in cancer through activating ferroptotic pathways and brings together the relevant
chemotherapeutics-based and nanotherapeutics-based studies to offer a perspective
for researchers regarding the potential use of this mechanism in developing novel therapeutic
strategies.
