Title:Reviewing Antiviral Research against Viruses Causing Human Diseases -
a Structure-Guided Approach
Volume: 15
Author(s): Arunima Sikdar*, Rupali Gupta and Evzen Boura*
Affiliation:
- University of Tennessee Health Science Center, Memphis, TN 38163, USA
- Institute of Organic Chemistry and Biochemistry
of the Czech Academy of Sciences, Prague, Czech Republic
- University of Tennessee Health Science Center, Memphis, TN 38163, USA
- Institute of Organic Chemistry and Biochemistry
of the Czech Academy of Sciences, Prague, Czech Republic
Keywords:
Antivirals, virus, cancer, drug design, COVID-19, structural biology, X-ray crystallography, cryo-EM.
Abstract: The smallest of all the pathogens, viruses, have continuously been the foremost strange
microorganisms. Viral infections can cause extreme sicknesses as evidenced by the HIV/AIDS
widespread or the later Ebola or Zika episodes. Apprehensive framework distortions are also regularly
observed as consequences of numerous viral infections. Besides, numerous viral infections
are of oncoviruses, which can trigger different types of cancer. Nearly every year, a modern infectious
species emerges, debilitating the world population with an annihilating episode. Subsequently,
there is a need to create antivirals to combat such rising infections. From the discovery of the antiviral
drug Idoxuridine in 1962 to the revelation of Baloxavir marboxil (Xofluza) that was approved
by the FDA in 2018, the whole process and criteria of creating antivirals have changed significantly.
In this article, different auxiliary science strategies are described that can serve as a referral
for therapeutic innovation.
