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Current Cardiology Reviews

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ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

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General Review Article

Resistin and Cardiovascular Disease: A Review of the Current Literature Regarding Clinical and Pathological Relationships

Author(s): Lutfu Askin*, Sabri Abus and Okan Tanriverdi

Volume 18, Issue 1, 2022

Published on: 29 July, 2021

Article ID: e290721195114 Pages: 7

DOI: 10.2174/1573403X17666210729101120

Abstract

Serum resistin, mainly secreted by the bone marrow, monocytes, and macrophages, contributes to many processes, including endothelial dysfunction, Vascular Smooth Muscle Cell (VSMC) proliferation, and atherothrombosis demonstrating effects on the development of hypertension and Coronary Artery Disease (CAD). Previously published clinical studies have shown that plasma resistin levels are significantly associated with cardiovascular disease risk factors and adverse clinical outcomes associated with the condition. Resistin is associated with vascular smooth muscle cell dysfunction in vitro, most plausibly due to its relationship with oxidative stress in advanced atherosclerosis whereas in vivo studies have shown resistin to be associated with intimal hyperplasia. We aimed to summarize the role of resistin on cardiovascular disease (CVD), as we could not find any review focused on the role of resistin on CVD.

Keywords: Atherosclerosis, coronary artery disease, resistin, endothelial dysfunction, intimal hyperplasia, hypertension.

Graphical Abstract

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