Title:Serum Arylsulfatase and Acid Phosphatase Activity in Patients with Metabolic Syndrome as a Result of Oxidative Damage to Lysosomes
Volume: 28
Issue: 11
Author(s): Dorota M. Olszewska-Słonina*
Affiliation:
- Department of Pathobiochemistry and Clinical Chemistry, Faculty of Pharmacy, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz,Poland
Keywords:
Acid phosphatase, arylsulfatase, lysosomal enzymes, metabolic syndrome, visceral obesity, triglycerides.
Abstract:
Background: Metabolic and clinical disorders forming the complex of interrelated abnormalities
is known as metabolic syndrome (METs).
Objective: Our goal was to assess the dependence of serum arylsulfatase (AS) and acid phosphatase
(ACP) activities on anthropometric and biochemical parameters in patients with METs.
Methods: In 142 patients with METs (IDF criteria), consisting of different components in different
sequences (hypertension, diabetes, lipid disorders), and in 65 healthy participants, basic biochemical
parameters were determined in laboratory tests. The activity of serum hydrolases was determined
using Bessey’s (ACP) and Roy’s (AS) methods.
Results: The AS activity is correlated with waist-to-hip ratio (WHR) (more strongly in women and
in most advanced METs), BMI (in men), and triglycerides (TG) (in women, participants with I degree
obesity, and those with three METs components). The ACP activity correlated with the WHR
of patients with II degree obesity, TG in those with III degree of obesity, and total cholesterol (TC)
in those with four METs components.
Conclusion: Increased AS activity in patients with METs compared to lower AS activity in the control
group may be due to decreased lysosomal function and related to the amount of adipose tissue.
Low activity of ACP in the blood serum of patients with METs compared to high activity of ACP
in the control group may indicate exhaustion of the lysosomal apparatus and loss of hydrolytic activity.
The increase in TG and TC in groups with an increasing number of METs-defining components
may be due to the abnormal lysosomal degradation of these compounds.
