Title:Structure and Functions of Bacterial Outer Membrane Protein A, A Potential Therapeutic Target for Bacterial Infection
Volume: 21
Issue: 13
Author(s): Qingfeng Guan, Biswajit Bhowmick, Archana Upadhyay and Qian Han*
Affiliation:
- Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences, Hainan University, Haikou, Hainan 570228,China
Keywords:
OmpA, Structure, Function, Therapeutic target, Gram-negative bacteria, Biofilm.
Abstract: Outer membrane protein A (OmpA) is a unique outer membrane protein which is abundantly
present in the outer membrane of Gram-negative bacteria. OmpA is a transmembrane structural
protein with a conserved amino acid sequence among different bacteria. This protein is involved
in a number of functions like adhesion, toxicity, invasiveness, and biofilm formation in
Gram-negative bacteria. Many studies have proposed that OmpA could be a therapeutic target for
bacterial infection. Our review focusses on the studies involving recent development in the structure
and functions of OmpA and further discussing its potential as a therapeutic target for bacterial
infection.
