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Review Article

HuR作为癌症的治疗靶点：未来会怎样

卷 29, 期 1, 2022

发表于: 28 June, 2021

页: [56 - 65] 页: 10

弟呕挨: 10.2174/0929867328666210628143430

价格: $65

摘要

ELAV样蛋白1或HuR（人抗原R）是一种RNA结合蛋白，在人类中由ELAVL1基因编码，其最佳功能之一是稳定mRNA以调节基因表达。HuR蛋白过表达无疑与肿瘤生长，进展和转移的风险增加有关，使其成为癌症的潜在治疗靶点候选者。干扰HuR表达的新型药物已经在体外和体内进行了测试，并取得了有希望的结果。本文的目的是回顾现有文献中关于可以积极作用和抑制HuR表达的潜在因子。HuR分子控制各种原癌基因，细胞因子和生长因子的表达，是肿瘤进展，侵袭和转移的主要参与者，并构成癌症治疗的新兴靶标。对PubMed数据库进行了彻底搜索，并纳入了所有已发表的文章，这些文章提供了通过HuR抑制表现出抗肿瘤作用的分子的科学数据。根据这些数据，HuR抑制应该是癌症治疗中一个有希望的靶点。

关键词: HuR蛋白，癌症治疗，HuR抑制，小分子，miRNA，siRNA。

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