Title:Transition Metal-mediated Uncaging Chemistry in Prodrug Design
Volume: 21
Issue: 24
Author(s): Hai Yang Shu, Ren De Zhu, Jing Wu, Xin Hua Liu and Jing Bo Shi*
Affiliation:
- School of Pharmacy, Anhui Medical University, Hefei, 230032,China
Keywords:
Transition metals, Prodrug design, Biocompatibility, Uncaging chemistry, Targeted drug delivery, TM catalyst.
Abstract: Uncaging chemistry catalyzed by transition metals is developed from deprotection reactions
and metal-organic catalytic reactions. Also, it has the characteristics of high efficiency, simplicity
and rapidity in the living biological system. In the past decade, metal encapsulation systems (such
as nanoparticles) and metal complexes have been developed to reveal the reactivity of transition metals
(including palladium, ruthenium, and gold) in biological systems. Metal nanostructures provide
huge possibilities for targeted drug delivery, detection, diagnosis and imaging. So far, palladium,
ruthenium and gold nano-architectures have dominated the field, but there are some problems that
hinder their wide application in clinical practice. In this review, based on palladium, ruthenium, gold
and their complexes, the application of prodrug design through uncaging reaction has been widely
discussed.
