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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

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Research Article

Structural Phylogeny of Different Allergens May Reveal Common Epitopic Footprint

Author(s): Anubhab Laha, Rajib Bandopadhyay* and Anindya Sundar Panja

Volume 28, Issue 10, 2021

Published on: 22 June, 2021

Page: [1099 - 1107] Pages: 9

DOI: 10.2174/0929866528666210622145710

Price: $65

Abstract

Background: The incidence of allergy has been increasing at an alarming rate over the last few decades.

Objective: Our present study aims to find out the structurally homologous motifs present in different proteinaceous allergens.

Methods: Significant number of protein sequences and their corresponding structures of various pollen, fungal, bacterial, and food allergens were retrieved and the sequence and structural identity were analyzed.

Results: Intra- and inter-sequence along with their structural analysis of the proteinaceous allergens revealed that no significant relationships exist among them. A few, but not the negligible number of high structural similarities, were observed within different groups of allergens from fungus, angiosperms, and animals (Aves and Mammalia).

Conclusion: Our in silico study on thirty-six different allergens showed a significant level of structural similarities among themselves, regardless of their sequences.

Keywords: Allergy, allergen, epitope, hypersensitivity, structural homology, protein sequences.

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