Title:A Mini-Review on the Effectiveness of Peptoids as Therapeutic Interventions against Neurodegenerative Diseases
Volume: 22
Issue: 7
Author(s): Subha Sankar Paul and Goutam Biswas*
Affiliation:
- Department of Chemistry, Cooch Behar Panchanan Barma University, Panchanan Nagar, Cooch Behar 736101,India
Keywords:
β-amyloid proteins, neurodegenerative disease, peptoids, peptidomimetics, therapeutics, proteolytic degradation.
Abstract:
Neurodegenerative diseases have emerged as one of the major age-associated diseases in
recent years. Hence, the urge to understand the mechanism and to find targeted therapeutics becomes
inevitable. Peptide-based compounds have emerged as one of the important tools for their
therapy. However, due to a lack of tolerability, specificity, and proteolytic degradation, they have
lost their applicability in the broader sense.
Thus, the search for suitable alternatives or peptidomimetics becomes an important criterion for
neurotherapeutics. One of the versatile peptidomimetics is N-substituted glycines or peptoids, which
retain many properties of peptides but successfully evade the drawbacks of peptides. Peptoids are
manifested with greater cellular permeability, less immunogenicity, and their ability to be administered
intra-nasally. These properties enhance their potential as neurotherapeutics with respect to
their peptide counterparts. Recently, peptoids have been explored for neurotherapeutic applications
as aggregation inhibitors, cell signaling pathways modulators, and agents for inhibiting inflammation
via multiple mechanisms. Peptoids, due to their versatility and low production cost, are becoming
popular among peptidomimetics as potential neurotherapeutic agents. In this review, the diverse
applications of peptoids with respect to neurodegenerative disease have been explored.
