Title:Recent Advances in siRNA Delivery Systems for Prostate Cancer Therapy
Volume: 23
Issue: 4
Author(s): Shahin Aghamiri*, Pourya Raee, Shiva Shahmohamadnejad, Sasan Shabani, Jaber Ghorbani, Marzieh Sameni and Mohammad Taha Ebrahimi
Affiliation:
- Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of
Medical Sciences, Tehran, Iran
- Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical
Sciences, Tehran, Iran
Keywords:
Prostate cancer, nanoparticles, siRNA, drug delivery systems, multidrug resistance, combination therapy.
Abstract: Abstract: The critical problems of conventional prostate cancer therapeutic strategies like nonspecific
toxicity and multi-drug resistance prompted the development and application of countless nanoparticle-
based siRNA therapeutics. Unfortunately, siRNA-based therapeutics suffer from the lack of
safe and effective delivery systems, immune system stimulation, poor knowledge of nano-bio interactions,
and limitations concerning designing, manufacturing, clinical translation, and commercialization.
In this review, we provide cutting-edge advances in nanoparticle-mediated siRNA delivery
carriers like polymeric systems, lipid systems, specific systems, and rigid nanoparticles for the treatment
of prostate cancer. Moreover, co-delivery of conventional chemotherapy drugs with siRNA as a
revolutionary robust strategy for prostate cancer combinational therapy is completely covered.
