Title:Effect of Modifications in Poly (Lactide-co-Glycolide) (PLGA) on Drug Release and Degradation Characteristics: A Mini Review
Volume: 18
Issue: 10
Author(s): Sweta Singh*Prabha Singha
Affiliation:
- Department of Pharmaceutics, Dr Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai,India
Keywords:
PLGA, acid capped, degradation, tissue engineering, erosion, matrix.
Abstract: The use of PLGA in the pharmaceutical industry has only increased as we move towards
more and more advanced delivery carrier systems. The qualities of PLGA like biocompatibility,
biodegradability and a tunable degradation and drug release has only helped in keeping up the release
requirements desired for various delivery platforms. Fine-tuning the release and degradation
rate is gaining more and more attention as researchers keep pushing the boundaries of novel delivery
carriers. Various experiments are being performed to understand the degradation behavior of
PLGA under various physiological and process-related conditions. The understanding of these parameters
has helped formulate various ways in which one can fine-tune the properties that can lead
to the release of active ingredients encapsulated within. Various techniques have been tried and tested
including changes like chemical modification, physical blending and surface modifications and
have found to be effective means of release modulation in delivery systems like parenteral, orals,
topicals and tissue engineering scaffolds. In this review, all these experiments and implications
thereon have been discussed in detail.
