Title:Carvacrol as a Potential Neuroprotective Agent for Neurological Diseases: A Systematic Review Article
Volume: 20
Issue: 10
Author(s): Mohammad Yassin Zamanian, Małgorzata Kujawska, Marjan Nikbakhtzadeh, Amin Hassanshahi, Soudeh Ramezanpour , Zahra Kamiab and Gholamreza Bazmandegan*
Affiliation:
- Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan,Iran
Keywords:
Anti-inflammatory, antioxidant, carvacrol, neurological diseases, neuroprotection, TRPC1, TRPM7.
Abstract:
Background and Objective: Neurological diseases are becoming a significant problem
worldwide, with the elderly at a higher risk of being affected. Several researchers have investigated
the neuroprotective effects of Carvacrol (CAR) (5-isopropyl-2-methyl phenol). This review systematically
surveys the existing literature on the impact of CAR when used as a neuroprotective agent
in neurological diseases.
Methods: The systematic review involved English articles published in the last ten years obtained
from PubMed, Google Scholar, and Scopus databases. The following descriptors were used to
search the literature: “Carvacrol” [Title] AND “neuroprotective (neuroprotection)” [Title] OR
“stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, seizure, epilepsy [Title].
Results: A total of 208 articles were retrieved during the search process, but only 20 studies met
the eligibility criteria and were included for review. A total of 20 articles were identified, in which
the efficacy of CAR was described in experimental models of stroke, traumatic brain injury, Parkinson’s
disease, Alzheimer’s disease, epilepsy, and seizure, through motor deficits improvements in
neurochemical activity, especially antioxidant systems, reducing inflammation, oxidative stress
and apoptosis as well as inhibition of TRPC1 and TRPM7.
Conclusion: The data presented in this study support the beneficial impact of CAR on behavioural
and neurochemical deficits. CAR benefits accrue because of its anti-apoptotic, antioxidant, and anti-
inflammatory properties. Therefore, CAR has emerged as an alternative treatment for neurological
disorders based on its properties.
