Title:The Role of Cholesterol Homeostasis in Diabetic Kidney Disease
Volume: 28
Issue: 36
Author(s): Xinyun Chen, Qinghua Yin, Liang Ma* Ping Fu
Affiliation:
- Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041,China
Keywords:
Cholesterol, diabetic kidney disease, SREBP2, LDLR, ABCA1, ABCG1.
Abstract: Considerable evidence has proved that disturbed cholesterol metabolism
played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions
were found in intrinsic renal cells of diabetic kidney disease patients and animal models,
causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions,
podocyte injury, and microalbuminuria of diabetic kidney disease. In this review,
we summarized the process of disturbed cholesterol metabolism and discussed how it induced
kidney dysfunction in diabetic kidney disease.
