Title:Structure, Function and Modulation of Striatal-enriched Protein Tyrosine Phosphatase (STEP)
Volume: 28
Issue: 37
关键词:
纹状体富集蛋白酪氨酸磷酸酶，神经系统疾病，抑制剂，激活剂，构效关系，PTP 结构域。
摘要: Striatal-enriched protein tyrosine phosphatase (STEP) is exclusively expressed
in the central nervous system and regulates various neuronal signaling factors through the
dephosphorylation of different substrates. Dysregulated expression or uncontrollable enzymatic
activity of STEP contributes to neurological disorders such as Alzheimer's disease,
which makes it a promising pharmaceutical target. Herein, we have reviewed the
structure and biological functions of STEP, as well as the recent development of smallmolecule
STEP modulators. We hope this review will provide a reference for the further
development of more potent and selective STEP inhibitors for the treatment of nervous
system diseases.
