Title:Structure, Function and Modulation of Striatal-enriched Protein Tyrosine Phosphatase (STEP)
Volume: 28
Issue: 37
Author(s): Xiao Liang, Xuben Hou* Hao Fang*
Affiliation:
- Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Ji’nan, Shandong 250012,China
- Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Cheeloo College of Medicine, Shandong University, Ji’nan, Shandong 250012,China
Keywords:
Striatal-enriched protein tyrosine phosphatase, nervous system diseases, inhibitor, activator, structureactivity
relationships, PTP domain.
Abstract: Striatal-enriched protein tyrosine phosphatase (STEP) is exclusively expressed
in the central nervous system and regulates various neuronal signaling factors through the
dephosphorylation of different substrates. Dysregulated expression or uncontrollable enzymatic
activity of STEP contributes to neurological disorders such as Alzheimer's disease,
which makes it a promising pharmaceutical target. Herein, we have reviewed the
structure and biological functions of STEP, as well as the recent development of smallmolecule
STEP modulators. We hope this review will provide a reference for the further
development of more potent and selective STEP inhibitors for the treatment of nervous
system diseases.
