Title:MicroRNAs as Biomarkers in Hypertrophic Cardiomyopathy: Current State of the Art
Volume: 28
Issue: 36
关键词:
肥厚性心肌病、心肌病、miRNA、纤维化、肥大、生物标志物。
摘要:
Background: Hypertrophic Cardiomyopathy (HCM) is the most common inherited
Cardiomyopathy. The hallmark of HCM is myocardial fibrosis that contributes to
heart failure, arrhythmias and sudden cardiac death.
Objective: Currently, there are no reliable serum biomarkers for the detection of myocardial
fibrosis, while cardiac magnetic resonance (CMR) is an imaging technique to detect
myocardial fibrosis. MicroRNAs (miRNAs) have been increasingly suggested as biomarkers
in cardiovascular diseases. However, in HCM there is as yet no identified and
verified specific circulating miRNA signature.
Methods: We conducted a review of the literature to identify the studies that indicate the
possible roles of miRNAs in HCM.
Results: From studies in transgenic mice with HCM, miR-1, -133 may identify HCM in
the early asymptomatic phase. Human miR-29a could be used as a circulating biomarker
for detection of both myocardial hypertrophy and fibrosis in HCM, while it could also
have a possible additional role in discrimination of hypertrophic obstructive cardiomyopathy
from non-obstructive HCM. Additionally, miR-29a-3p is associated with diffuse myocardial
fibrosis in HCM, while miR-1-3p could discriminate end-stage HCM from dilated
cardiomyopathy and left ventricle dilation. Another role of miRNAs could also be the
contribution in the differential diagnosis between HCM and phenocopies. Moreover, miRNA-
targeted therapy (miR-133 mimics) is promising in inhibiting cardiac hypertrophy,
but this is still in the early stages.
Conclusion: A more reliable and specific signature of miRNAs is expected with forthcoming
studies in samples from HCM patients and correlation of miRNAs with CMR
and serum markers of fibrosis may implicate novel diagnostic and therapeutic pathways.
