Title:Preparation, Pharmacokinetic and Application of Gold Nanoclusters (AuNCs) in Tumor Treatment
Volume: 28
Issue: 34
关键词:
金纳米团簇、药代动力学、光热疗法、生物成像、药物输送、放射增敏剂。
摘要: As a new type of nanomaterials, the gold nanoclusters (AuNCs) perform many
special physical and chemical properties, such as large Stokes shift, relatively simple preparation,
good water solubility, low toxicity, and good biocompatibility, which make
them show infinite potential in various fields, especially in cancer treatment. In recent
years, great progress has been made in the preparation, functionalization, and biomedical
applications of the AuNCs. In this article, the latest research progress and synthesis methods
of the AuNCs have been summarized, emphasizing the preparation using the “bottom-
up” synthesis strategy. Furthermore, we introduced the in vivo pharmacokinetic performance
of the AuNCs. In the last part, we exemplified the applications of the AuNCs
in biomedicine, including photothermal therapy (PTT), bioimaging, drug delivery, and radiotherapy
sensitization, which further confirmed the great potential of the AuNCs in tumor
treatment.
