Title:Dissecting the Therapeutic Potency of Antimicrobial Peptides Against Microbial Biofilms
Volume: 22
Issue: 4
Author(s): Payal Gupta*, Purusottam Mishra, Ramasare Prasad and Krishna Mohan Poluri*
Affiliation:
- Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand,India
- Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand,India
Keywords:
Antimicrobial peptides, biofilm, synergistic, nano-formulation, antibiotic resistance, polymeric micelles.
Abstract: Microbial resistance to conventional therapeutics has become a significant threat to human
society. Biofilms serve as the major virulence factor for the microorganisms by resisting the
antibiotics and host innate immune system. Antimicrobial peptides (AMPs) have emerged as a potential
alternative to conventional therapeutics due to their exceptional anti-biofilm and broad-spectrum
antimicrobial property. Researchers have applied bioinformatics, genetic engineering, tissue
culture, and drug delivery approaches to enhance the production and therapeutic efficacy of antimicrobial
peptides. This review comprehensively describes the various aspects of AMPs with particular
focus on their anti-biofilm potential. Other detailed information highlighted in this review includes
different classes of AMPs, their mode of action, and anti-biofilm activity both alone and in
synergy with other AMPs or conventional antibiotics. Further, challenges and opportunities of
AMPs based drug delivery systems such as nano-formulations, polymeric micelles, and vesicles
are also summarized.
