Title:Leukaemia Infection Diagnosis and Intestinal Flora Disorder
Volume: 22
Issue: 1
关键词:
肠道菌群失调,儿童,白血病,感染,诊断,治疗。
摘要: Leukaemia is the most common malignant tumor in childhood and can be
cured by chemotherapy. Infection is an important cause of treatment-related death and
treatment failure in childhood leukaemia. Recent studies have shown that the correlation
between the occurrence of leukaemia infection and the intestinal flora has attracted
more and more attention. Intestinal flora can affect the body's physiological defense and
immune function. When intestinal microflora disorder occurs, metabolites/microorganisms
related to intestinal flora alterations and even likely the associated morphofunctional
alteration of the epithelial barrier may be promising diagnostic biomarkers for
the early diagnosis of leukaemia infection. This review will focus on the interaction
between leukaemia infection and intestinal flora, and the influence of intestinal flora in
the occurrence and development of leukaemia infection.