Title:Ultrasound-Triggered Immunotherapy for Cancer Treatment: An Update
Volume: 22
Issue: 6
Author(s): Debasmita Mukhopadhyay, Amal Ahmed, Catherine Sano, Nahid Awad, Nour Al Sawaftah and Ghaleb A. Husseini*
Affiliation:
- Chemical Engineering Department, American University of Sharjah, Sharjah,United Arab Emirates
Keywords:
Ultrasound, immunotherapy, liposome, microbubbles, cancer, cell growth.
Abstract: Over the past few decades, immunotherapy has emerged as a promising therapeutic approach
to treat some types of cancer. Moreover, antibody-based cancer therapies can trigger apoptosis
and cell growth inhibition to induce immune cell destruction of target cells through antibody-dependent
cellular cytotoxicity (ADCC). Nevertheless, immunotherapeutic efficiency is often restricted
due to deficient delivery or low accumulation of therapeutic molecules at the tumor site. The development
of pegylated liposomes with monoclonal antibodies conjugated to their surfaces (immunoliposomes)
and triggered with ultrasound can effectively improve drug accessibility by enhancing
cell membrane permeability and drug release. This review summarizes existing traditional
cancer treatments and their limitations, emphasizing the recent advancements in ultrasound-triggered
immunotherapy.
