Title:Recent Progress on Apoptotic Activity of Triazoles
Volume: 22
Issue: 16
Author(s): P. Çıkla-Süzgün and Ş.G. Küçükgüzel*
Affiliation:
- Vocational School of Health Services, Fenerbahçe University, Ataşehir, 34758, Istanbul,Turkey
Keywords:
Apoptosis, triazole, cancer, caspase-8, caspase-3, Bcl-2, cytochrome C.
Abstract: Apoptosis is often called programmed cell death and is defined as a self-directed cell destruction
process. It is different from necrosis due to the activation of caspases during this process.
Apoptosis is directly related to cancer progression and plays a vital role in carcinogenesis; all cytotoxic
drugs and radiation therapy programs initiate apoptosis in tumor cells. Today, studies show that
heterocyclic compounds that contain triazole functionality have anticancer activities; triazoles are 5-
membered rings, which contain two carbon and three nitrogen atoms. Therefore, many researchers
have synthesized these small active compounds as target structures and evaluated their apoptotic activities.
The present review describes recent medicinal aspects of triazoles as anticancer agents that
have been reported during the past few years. We hope that the bioactivity of triazole derivatives will
be beneficial for the rational design of a new generation of small molecule drugs.
