Title:New Genetic Polymorphisms as an Epidemiological Factor of Arterial
Hypertension in Patients with Hyposodical Diet
Volume: 18
Issue: 1
Author(s): Sabina López-Toledo, Sergio A. Ramírez-García*, Carlos E. Cabrera-Pivaral, Luis Javier Flores-Alvarado, Dalia Madrigal Ruiz, María E. Aguilar Aldrete and Felipe Parada-Luna
Affiliation:
- Instituto de Nutrición, Universidad de la Sierra Sur. Miahuatlán de Porfirio Díaz, Oaxaca, Mexico
Keywords:
Genetics, hypertension, polymorphism, epigenomics, epidemiology, haplotypes.
Abstract: Hypertension is a major public health problem, affecting more than a quarter of the
world's population causing serious cardiovascular problems. In recent years, different polymorphisms
have been studied and helped to identify some candidate genes and hereditary syndromes
associated with the molecular mechanisms involved in the development of hypertension. Therefore,
it is important to identify these molecular mechanisms. This review exposes all the genes and
polymorphisms that increase or decrease the risk of hypertension in different populations that are
related to the renin angiotensin aldosterone system, G protein, salt excretion, aldosterone synthesis,
lipid metabolism, mechanism of insulin resistance, vitamin metabolism, purines and sodium reabsorption.
This document can be a useful tool in clinical practice, in addition to serving as a support
for future research on this topic.
